Figure S4.

Hypoxia exacerbates pulmonary arterial hypertension in diet-resistant/diet-induced obesity (DR/DIO) and Zucker lean/fatty rat models. Left, eight-week-old male DR and DIO rats were fed either a low-fat (white bars) or a high-fat (black bars) diet ad lib. for 5 months. Right, eight-week-old male Zucker lean (white bars) or fatty (hatched bars) were fed standard chow for 5 months. Separate cohorts of rats were exposed to hypoxia (Hypox) for the last weeks of the treatment regimen. Mean pulmonary artery (PA) pressure (mmHg) was measured as described in “Methods.” There were 2 experiments, with 6 animals per group for each experiment. *P < .05 compared to the DR normoxic (Normox) cohort (left) or to the normoxic cohort (right).