Figure 2.

Survival in the modern pulmonary arterial hypertension (PAH) management era compared with that in the original National Institutes of Health (NIH) registry. Kaplan-Meier survival estimates in the combined population of patients with PAH (black line) are shown. When the predictive modeling approach of the NIH registry was used, the estimated survival (gray line) was ∼10% lower than what was actually observed. Adapted with permission from Humbert et al.¹²