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. 2014 Dec 10;8(12):12386–12396. doi: 10.1021/nn505047n

Figure 2.

Figure 2

Nanocomplex morphology characterization and retinoic acid release. TEM images of naked gold nanoparticles (A) and multifunctional nanocomplexes (B). Dynamic light scattering (DLS) analysis: (C) naked gold nanoparticles in pure water; (D) multifunctional nanocomplexes in PBS. (E) Principle of Schiff base mediated stimulating motif (retinal) self-cleavage and oxidization under different physiological pH values. (F) HPLC chromatogram of corresponding released retinal or retinoic acid under different pH values and time points. The duplicate peak from the 30 min RA release chromatogram is attributed to the mixture of retinal and retinoic acid in solution.