Figure 2.

Targeted theranostic PLGA nanoparticles dual-loaded with SPIO and docetaxel for concurrent MR imaging and cancer therapy. (left) A schematic of the nanotheranostic formulation. (right) T2-weighted imaging of PC3 cells (1 × 10⁶) after 2 h of incubation with (a) targeted SPIO/docetaxel-loaded nanoparticles, (b) nontargeted SPIO/docetaxel-loaded nanoparticles, and (c) Endorem (a commercially available MRI contrast agent) at Fe concentrations of 0, 5, 10, 20, 40, and 80 μg/mL; cells were then mixed with 2% agarose solution in PBS and scanned under a 1.5 T MRI scanner at room temperature. Reproduced with permission from reference (50).