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. Author manuscript; available in PMC: 2015 Jun 11.
Published in final edited form as: N Engl J Med. 2014 Nov 13;371(24):2277–2287. doi: 10.1056/NEJMoa1409354

Figure 1. Detection of Autoantibodies against an Unknown Antigen in Patients with Membranous Nephropathy.

Figure 1

Panel A shows reactivity of serum samples with human glomerular extracts (HGE). Four of the initially tested samples from patients with membranous nephropathy (MN) reacted with a glomerular protein approximately 250 kD in size (MN 1 through MN 4) but not with the recombinant phospholipase A2 receptor (rPLA2R1). Panels B and C show overall reactivity in the European and Boston cohorts, respectively. FSGS denotes focal segmental glomerulo-sclerosis, and MCD minimal-change disease. The number above each column indicates the fraction of samples positive for a 250-kD protein.