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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Transl Res. 2014 Mar 25;164(1):70–83. doi: 10.1016/j.trsl.2014.03.007

Figure 3. p-Stat3 expression is decreased in Epim−/− DSS treated colon.

Figure 3

p-Stat3 expression in Epim−/− descending colon was examined by immunoblot. Representative blots of two separate experiments are shown (A). p-Stat3 band intensity relative to that of the loading protein tubulin was measured. As expected, there is minimal to no p-Stat3 expression in untreated animals. All animals expressed un-phosphorylated Stat3. Only WT mice expressed Epim. The bottom row shows the loading protein tubulin. After treatment with DSS, there is a blunted increase in p-Stat3 expression in Epim−/− versus WT colon. (B) Quantification of band intensity confirms that p-Stat3 expression remained significantly less in the DSS treated Epim−/− (n=7) compared to WT (n=6) colon.