Table 3.
Correlation between AS genes and the clinicopathologic characteristics of CSCC patients
| Variable feature | n |
KLHDC7B
|
P-value |
SYCP2
|
P-value | ||
|---|---|---|---|---|---|---|---|
| + | − | + | − | ||||
| Age | |||||||
| ≥40 | 24 | 17 | 7 | 0.304 | 6 | 18 | 0.104 |
| <40 | 16 | 10 | 6 | 8 | 8 | ||
| Differentiation | |||||||
| Good | 17 | 10 | 7 | 0.012 | 5 | 12 | 0.058 |
| Moderate | 16 | 12 | 4 | 7 | 9 | ||
| Poor | 7 | 5 | 2 | 2 | 5 | ||
| Tumor size (cm) | |||||||
| ≥4.0 | 18 | 16 | 2 | 0.016 | 9 | 9 | 0.072 |
| <4.0 | 22 | 11 | 11 | 5 | 17 | ||
| Lymphatic metastasis | |||||||
| Yes | 8 | 5 | 3 | 0.736 | 3 | 5 | 0.868 |
| No | 32 | 22 | 10 | 11 | 21 | ||
| Cervical invasion | |||||||
| ≥1/2 | 12 | 8 | 4 | 0.94 | 8 | 4 | 0.006 |
| <1/2 | 28 | 19 | 9 | 6 | 22 | ||
| FIGO staging | |||||||
| Ia | 6 | 4 | 2 | 0.518 | 1 | 5 | 0.495 |
| Ib | 27 | 17 | 10 | 11 | 16 | ||
| IIa | 7 | 6 | 1 | 2 | 5 | ||
Note: Fisher’s exact text was used when theoretical frequency was <5.
Abbreviations: AS, alternative splicing; CSCC, cervical squamous cell carcinoma; FIGO, International Federation of Gynecology and Obstetrics; KLHDC7B, kelch domain-containing 7B; SYCP2, synaptonemal complex 2.