Table 2.

Correlation between APAF-1, cathepsin B, Ki-67, p53, and various clinicopathological features in patients with pituitary adenomas

	Parameters	APAF-1				Cathepsin B
		<25%	>25%	χ2	P-value	<50%	>50%	χ2	P-value
Sex	Male	9	6	2.143	0.14	6	9	3.394	0.065
	Female	5	10			11	4
Age	<60 years	11	13	0.033	0.85	14	10	0.136	0.712
	>60 years	3	3			3	3
Invasiveness	Invasive	14	8	9.54	0.002	9	13	8.342	0.003
	Noninvasive	0	8			8	0
Functionality	Functional	11	5	6.71	0.0095	7	9	2.33	0.126
	Nonfunctional	3	11			10	4
Ki-67	>3%	12	8	4.28	0.038	8	12	6.787	0.0091
	<3%	2	8			9	1
p53	+	8	2	6.696	0.0096	0	10	19.61	<0.001
	−	6	14			17	3
APAF-1	<25%					4	10	8.438	0.00367
	>25%					13	3
Cathepsin B	>50%	10	3	8.438	0.00367
	<50%	4	13

Abbreviation: APAF-1, apoptotic protease-activating factor-1.