Table 1. Characteristics and HPV status of invasive laryngeal cancer cases (n = 148).
| No. | % | |
| Sex | ||
| Male | 121 | 81.8 |
| Female | 27 | 18.2 |
| Age at diagnosis (years) | ||
| <60 | 43 | 29.1 |
| ≥60 | 105 | 70.9 |
| Race/ethnicity | ||
| White | 106 | 71.6 |
| Asian | 26 | 17.6 |
| Pacific Islander | 11 | 7.4 |
| Black | 5 | 3.4 |
| Year of diagnosis | ||
| 1993–1998 | 91 | 61.5 |
| 1999–2004 | 57 | 38.5 |
| Stage 1 , 2 | ||
| Localized | 93 | 66.9 |
| Regional involvement | 29 | 20.9 |
| Metastatic | 17 | 12.2 |
| Grade 3 | ||
| Well-differentiated | 17 | 12.6 |
| Moderately differentiated | 89 | 65.9 |
| Poorly differentiated/undifferentiated | 29 | 21.5 |
| Subsite | ||
| Glottis | 92 | 62.2 |
| Supraglottis | 45 | 30.4 |
| Subglottis and other subsites4 | 11 | 7.4 |
| Histology | ||
| Squamous cell carcinoma (SCC), unspecified subtype | 123 | 83.1 |
| Keratinizing SCC | 15 | 10.1 |
| Large cell non-keratinizing SCC | 4 | 2.7 |
| Other5 | 6 | 4.0 |
| HPV | ||
| negative | 117 | 79.1 |
| positive | 31 | 20.9 |
| carcinogenic HPV | ||
| HPV 16 | 9 | 6.1 |
| HPV 18 | 3 | 2.0 |
| HPV 31 | 1 | 0.7 |
| HPV 33 | 9 | 6.1 |
| HPV 35 | 2 | 1.4 |
| HPV 39 | 1 | 0.7 |
| HPV 51 | 3 | 2.0 |
| HPV 66 | 2 | 1.4 |
| non-carcinogenic HPV | ||
| HPV 6 | 2 | 1.4 |
| HPV 11 | 1 | 0.7 |
| HPV 54 | 1 | 0.7 |
| HPV 70 | 1 | 0.7 |
| HPV 89 | 1 | 0.7 |
| HPV X6 | 2 | 1.4 |
1
Based on the SEER staging classification system defining the extent of disease involvement as localized, regional spread, and distant metastases.
2
Excludes 9 cases for which data on stage are missing.
3
Exclude 13 cases for which data on grade are missing.
4
Overlapping and unspecified lesions of the larynx.
5
Includes papillary SCC, spindle cell SCC, basaloid SCC, small cell neuroendocrine carcinoma.
6
HPV amplicon not hybridizing to any of the type-specific probes in the assay.