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. 2014 Dec 29;9(12):e115974. doi: 10.1371/journal.pone.0115974

Figure 3. Feeding with HFD for 16 weeks leads to cardiac dysfunction in mice.

Figure 3

(A) Upper panel: Representative images of M mode of echocardiography. Low panel: Feeding mice with HFD for 16 weeks significantly impaired cardiac performance indicated by decreases in EF and FS levels in HFD mice compared to ND mice (n = 5–7 mice, *p<0.05). (B) Left ventricular end diastolic diameter (LVEDD) and left ventricular end diastolic volume (LVEDV) were significantly elevated in HFD mice compared to ND mice at 16 weeks (n = 5–7 mice, *p<0.05). (C and D) Expression of cardiac hypertrophic markers ANP and β-MHC in HFD and ND mice. The levels of ANP and β-MHC were significantly higher in the hearts of HFD mice than that of ND mice at 16 weeks (n = 6 mice, *p<0.05).