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. 2014 Dec 29;9(12):e115974. doi: 10.1371/journal.pone.0115974

Figure 8. Conditional knockout of PHD2 in HFD mice improves glucose tolerance and cardiac function.

Figure 8

(A) Conditional knockout of PHD2 in HFD mice significantly reduced body weight growth compared to WT, Cre+−HFD mice (n = 10 mice, *p<0.05). (B) Conditional knockout of PHD2 in normal chow diet mice significantly improved glucose tolerance compared to WT, Cre+ mice fed with ND (n = 7–10 mice, *p<0.05). (C) Conditional knockout of PHD2 in HFD mice significantly enhanced glucose tolerance compared to WT, Cre+−HFD mice (n = 10 mice, *p<0.05). (D and E) Conditional knockout of PHD2 in HFD mice significantly increased EF% and FS% compared to WT, Cre+−HFD mice (n = 5–7 mice, *p<0.05).