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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Mol Cancer Res. 2014 Sep 22;13(2):211–222. doi: 10.1158/1541-7786.MCR-14-0305

Figure 1. Telomere-interacting proteins and their roles.

Figure 1

a) The shelterin complex, composed of six proteins (left), and several of its associated proteins are depicted with the biological functions they play in the cell (right). For simplicity, TERF1 and TERF2 homodimers are drawn as single boxes. The alternative T- and D-loop telomere structures are shown. Tnk: Tankyrase, Ub: ubiquitination, P: phosphorylation, ADPr: ADP ribosylation. b) The members of the telomerase complex are shown bound to the G-strand overhang with a simplified structure for TERC, which provides the template for repeat addition.