Table 3. Plasma markers of hemostatic activity before and 5 min after lower body negative pressure (post-LBNP) was ceased because of presyncopal symptoms.
Baseline | Post-LBNP | P-value | |
PT (s) | 10.7±0.5 | 10.5±0.3 | 0.163 |
aPTT (s) | 27.7±2.0 | 27.1±1.8 | 0.081 |
vWF:Ag (IU l−1) | 1016 [610–1371] | 1292 [629–1743] | 0.078 |
vWF:RCo (% d.N.) | 115±46 | 128±47* | 0.024 |
FVIII (IU l−1) | 830±160 | 982±253* | 0.011 |
TAT (µg l−1) | 5.5±1.7 | 9.2±5.5 | 0.134 |
Protein C activity (% d.N.) | 199±26 | 214±26* | 0.007 |
t-PA (ng ml−1) | 0.1±1.6 | 1.7±2.3* | 0.017 |
D-dimer (mg l−1) | 0.25 [0.17–0.51] | 0.29 [0.19–0.56]* | 0.031 |
Prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor antigen (vWF:Ag), von Willebrand factor ristocetin cofactor (vWF:RCo), coagulation factor VIII (FVIII), thrombin-antithrombin III complex (TAT), and tissue-type plasminogen activator (t-PA). Mean±SD and median [range], n = 7 (except for t-PA and D-dimer, n = 6), * significantly different from baseline, using the Benjamini-Hochberg procedure with a false discovery rate of 0.05.