Table 2.
Genotype frequencies of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in the Japanese population (n=1017).
| Gene | Genotypes | Phenotypes | Number of subjects | Observed frequency (%) |
|---|---|---|---|---|
| CYP1A2 | *1A/*1A | EM | 593 | 58.3 |
| *1A/*1C | IM | 372 | 36.6 | |
| *1C/*1C | PM | 52 | 5.1 | |
| CYP2C9 | *1/*1 | EM | 963 | 94.7 |
| *1/*3 | IM | 54 | 5.3 | |
| *3/*3 | PM | 0 | 0 | |
| CYP2C19 | *1/*1 | EM | 345 | 33.9 |
| *1/*2 | IM | 377 | 37.1 | |
| *1/*3 | IM | 142 | 14.0 | |
| *2/*2 | PM | 80 | 7.9 | |
| *2/*3 | PM | 63 | 6.2 | |
| *3/*3 | PM | 10 | 1.0 | |
| CYP2D6 | *1/*1 | EM | 387 | 38.1 |
| *1/*10 | IM | 375 | 36.9 | |
| *10/*10 | IM | 241 | 23.7 | |
| Undefined | 14 | 1.4 | ||
| CYP3A5 | *1/*1 | EM | 61 | 6.0 |
| *1/*3 | IM | 362 | 35.6 | |
| *3/*3 | PM | 594 | 58.4 |