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Melatonin attenuated mRNA expression of HIF-1 alpha, HIF-2 alpha and VEGF in hypoxic PC-3. PC-3 cells were treated in the absence or presence of melatonin (1mM) for 4 h under hypoxia. Total RNA was analyzed by qRT-PCR to determine the mRNA expression of HIF-1 alpha, HIF-2 alpha and VEGF. GAPDH was used to normalize the target gene. Data are presented as means ± SEM of three independent experiments. # p< 0.05 vs normoxia control, * p<0.05 vs hypoxia control.
