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Silencing of p53 by siRNA blocks the expression of AChE induced by cisplatin in the nuclear but not in cytoplasm. MCF-7 cells were treated with100 μM cisplatin for 24 h in the absence or presence of p53 siRNA. Then the proteins either from nuclear or from cytoplasm were extracted for the western blot assay with the specific AChE, β-actin and Histone H2A antibodies.
