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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Clin Immunol. 2014 Oct 29;156(1):19–27. doi: 10.1016/j.clim.2014.10.007

Figure 5.

Figure 5

(A) DNA methylation status of CD4, CD8A, and CD8B in CD4+, CD8+, and DN T cell subsets. The average methylation fraction across all evaluated CG sites in each locus is depicted. CD4 is hypermethylated in DN and CD8+ T cells compared to CD4+ T cells (P =0.0027 and 0.0005, respectively), and similarly methylated in DN compared to CD8+ T cells (P = 0.62). CD8A was hypermethylated in DN and CD4+ T cells compared to CD8+ T cells (P = 0.0002 and 0.0001, respectively), and CD8B was hypermethylated in DN and CD4+ T cells compared to CD8+ T cells (P = 0.057 and 0.0001, respectively). All P values were calculated using Student's t test, and asterisk “*” represents P values of < 0.05. (B) The location of each CG site evaluated in the CD4 genetic locus and the average methylation fraction in each CG site individually across samples in DN and autologous CD4+ T cells are displayed.