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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Drug Test Anal. 2014 May 12;7(3):207–213. doi: 10.1002/dta.1656

Figure 1.

Figure 1

Extracted wavelength chromatogram (XWC) and Enhanced mass spectrum (EMS) of Tenofovir (TFV): Unstressed sample (1 mg mL−1) (A and B), and stressed samples under Acidic (0.1 M HCl), analyzed after day one (C and D); Alkaline (0.1 M NaOH), analyzed after day 5 (E and F); and Neutral (water) hydrolytic conditions, analyzed after day 5 (G and H), respectively. The inset figures C and D showed the XWC and EMS spectra of stressed samples of TFV under acidic (0.1 M HCl) conditions, analyzed after 5 days of reflux, respectively. The left and right panels of the Figure showed XWC and EMS spectrum, respectively. A1, A2, B1, and W1 are the degradation products of TFV as discussed in Figure 3.