TABLE 6.

Independent Associations of Neonatal Neuroimaging Findings With 18 to 22 Months’ Corrected Age Outcomes

Neuroimaging Adverse Finding	NDI or Death		Significant Gross Motor Impairment or Death
	Adjusted OR (95% CI)	P	Adjusted OR (95% CI)	P
Full model
Perinatal/neonatal factorsa + early CUS + late CUS + brain MRI
Early CUSb	0.7 (0.2–2.4)	.56	0.8 (0.2–3.3)	.77
Late CUSc	9.8 (2.8–35)	.0005	10.9 (2.5–47.3)	.0014
MRI moderate or severe WMA	1.5 (0.6–3.6)	.34	1.6 (0.5–4.9)	.45
MRI significant cerebellar lesions	3.0 (1.3–6.8)	.0078	5.2 (1.9–14.1)	.0012
Limited models
Perinatal/neonatal factors + early CUS+ brain MRI (excludes late CUS)
Early CUSb	1.8 (0.7–4.6)	.22	2.1 (0.7–6.7)	.19
MRI moderate or severe WMA	2.4 (1.1–5.2)	.024	2.8 (1.0–7.6)	.04
MRI significant cerebellar lesions	2.7 (1.3–5.9)	.01	4.5 (1.8–11.6)	.0017
Perinatal/neonatal factors + early CUS + late CUS (excludes MRI)
Early CUSb	1.0 (0.3–3.3)	.96	1.2 (0.3–4.6)	.74
Late CUSc	11.9 (3.6–39.8)	<.0001	13.2 (3.4–50.8)	.0002

^aPerinatal/neonatal factors included in the model for NDI or death: race, late sepsis, BPD, and postnatal steroids; and included in the model for significant gross motor impairment or death: race, multiple gestation, maternal insurance, late sepsis, BPD, and PNS.

^bEarly CUS composite adverse finding: grade III or IV ICH or cPVL.

^cLate CUS composite adverse finding: moderate or severe VE, or cPVL, or porencephalic cyst, or shunt.