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Binding characterization of TM6 mutant. Shown are competition curves for CCK, T-0632, and BDZ-1 to compete for binding radioligand, [125I]BDZ-1, to membranes from CHO cells expressing WT rat CCK1R (A) and the R337A mutant construct (B). Values represent percentages of maximal saturable binding that were observed in the absence of competitor. Data are expressed as means ± S.E.M. of duplicate determinations from three independent experiments.
