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. 2015 Jan;87(1):130–140. doi: 10.1124/mol.114.095430

Fig. 3.

Fig. 3.

Inhibition by T-0632 of the CCK-stimulated biologic responses in CHO-CCK1R cells. (A) Intracellular calcium responses in CHO-CCK1R cells incubated with increasing concentrations of T-0632, CCK, or CCK in the presence of a constant amount of T-0632 (0.1 μM). (B) Inhibition of intracellular calcium responses to 0.1 nM CCK in CHO-CCK1R cells incubated with increasing concentrations of T-0632. (C) IP1 responses in CHO-CCK1R cells incubated with increasing concentrations of T-0632, CCK, or CCK in the presence of a constant amount of T-0632 (0.1 μM). Data points represent means ± S.E.M. of data from three independent experiments performed in duplicate, normalized relative to the responses stimulated by 0.1 mM ATP (A), by 0.1 nM CCK in the absence of T-0632 (B), and by 10 μM CCK (C).