Fig. 4.

Antinociceptive activity of NAX 409-9 and representative analgesic compounds in the Seltzer PSNL model of neuropathic pain in rats (Seltzer et al., 1990). The sciatic nerve in the right hind leg of each rat was ligated 2 weeks prior to testing. Rats were injected (intraperitoneally) with the various compounds, at the doses listed above, and tested at various time points (1 hour, NAX 409-9, acetaminophen; 2 hours, morphine; or 4 hours, gabapentin), based on previous time course studies (data not shown). Data are presented as a percentage of predrug PWT. NAX 409-9 (2 mg/kg) increased the PWT in a manner comparable to that of morphine (2 mg/kg) and gabapentin (40 mg/kg), whereas acetaminophen was ineffective at 300 mg/kg. N = 8 for each group. *P < 0.05 compared with predrug PWT values.