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Effect of NAX 409-9 in the hot plate test for evaluation of acute antinociceptive activity. Following compound administration, mice were placed on a heated plate (55°C) within a plexiglass container. Mice were treated with either NAX 409-9, at 8 and 16 mg/kg, or morphine (15 mg/kg). Whereas morphine increased latency to hindpaw withdrawal, NAX 409-9 had no effect at the doses tested. N = 8–14 per group. **P < 0.01 compared with vehicle.
