. 2015 Jan;352(1):185–193. doi: 10.1124/jpet.114.219063

TABLE 1.

ED₅₀ [95% confidence interval (CI)] values for NAX 409-9 and representative analgesic compounds in the carrageenan model of thermal hyperalgesia

Compound	ED₅₀^a	95% CI^a
	mg/kg
NAX 409-9	6.6	5.6–7.8
Gabapentin	28.6	23.8–34.2
Ibuprofen	10.5	n.d.^b
Acetylsalicylic acid	49.3	29.8–81.4
Morphine	2.2	0.3–15.2

n.d., not determined.

^{^a}

ED₅₀ and CI values were calculated by identifying the number of animals in each treatment group protected (above 50% effect threshold, determined in vehicle-treated animals).

^{^b}

The CI for ibuprofen included all doses administered during testing.