Table 1.

IC₅₀ and f2 (concentration needed to increase baseline fluorescence two-fold) values for transporter inhibition assays for dovitinib and the corresponding control compound.

Protein Inhibited	Cell Model Used	Dovitinib f2 [µM]	Control Compound	f2 [µM]
P-gp	L-MDR1	48.4 ± 15.6	Verapamil	3.9 ± 1.9 [28]
		IC50 [µM]		IC50 [µM]
BCRP	MDCKII-BCRP	10.3 ± 4.5	Fumitremorgin C	0.7 ± 0.3 [37]
OATP1B1	HEK-OATP1B1	76.5 ± 28.9	Rifampicin	2.4 ± 0.9 [13]
OATP1B3	HEK-OATP1B3	105.2 ± 23.0	Rifampicin	2.1 ± 1.0 [13]