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Partitioning profile changes of FXN-p.Ile154Phe (FXN-I154F) and FXN-p.Asp122Tyr (FXN-D122Y) (both at 2 µM) in the absence (solid triangle) and presence (solid box) of 2 µM GroEL beads in the presence of 4 M glycerol ((A,C), respectively) or 1 M TMAO ((B,D), respectively). In both instances, the non-denaturing concentration of urea is 1 M at 45 °C. (A,C). The osmolyte solubility/partitioning profiles were compared with time dependent solubility changes without osmolytes.
