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. 2015 Jan 1;5(3):240–250. doi: 10.7150/thno.10226

Figure 2.

Figure 2

C40-tPEG-Ex4-Cys (PEG-Ex4) improves survival and restores left ventricular cardiac function after MI. Mice were subjected to MI and treated with PEG Ex4-P1, Ex4-P1 or Ex4-P2. The survival and left ventricular cardiac function were determined at different time points after operation. A, Kaplan-Meier survival curve. B-C, Echocardiographic analysis. LVFS, LV fractional shortening; MI, myocardial infarction; Ex4-P1, Exendin-4 treatment, protocol 1 (50 µg/kg of Ex4, IV bolus every 3 days); Ex4-P2, Exendin-4 treatment, protocol 2 (50 µg/kg of Ex4, IV bolus twice daily); PEG Ex4-P1, PEG-Ex4 treatment, protocol 1 (675 µg/kg of PEG-Ex4 (50 µg/kg equivalent of Ex4), IV bolus every 3 days). *P < 0.05 vs. MI, **P < 0.01 vs. MI; & P < 0.05 vs. Ex4-P1.