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. 2015 Jan 1;26(1):55–65. doi: 10.1091/mbc.E14-07-1200

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© 2015 Havrylenko, Noguera, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 5: — Teamwork between the Arp2/3 complex and VASP via mutual binding to WAVE. Membrane/bead-bound WAVE activates the Arp2/3 complex with its VCA domain, which then dissociates from the activated Arp2/3 complex to allow the new branch to grow, giving the scenario at the top, where the nascent branch could diffuse away from the surface. When WAVE recruits VASP in addition to binding and activating the Arp2/3 complex, a hand-off of the nascent branch could happen (bottom). VASP provides the link between the surface and the network at the same time that it enhances growth of new barbed ends. This could not only increase surface-directed polymerization on its own, but it could also contribute to providing new filament primers for subsequent rounds of Arp2/3 complex–based branching (bottom, right vignette).