Table 2.
HRs for Prediagnosis and Postdiagnosis LTPA and Mortality Among Individuals Diagnosed With Colorectal Cancer in the NIH-AARP Study
| Mortality | Prediagnosis LTPA (n = 3,797) |
Postdiagnosis LTPA (n = 1,759) |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Never/Rarely HR | < 1 h/wk |
1-3 h/wk |
4-7 h/wk |
> 7 h/wk |
P (trend) | 0 h/wkHR | 0 to < 1 h/wk |
1 to < 4 h/wk |
4 to < 7 h/wk |
≥ 7 h/wk |
P (trend) | |||||||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | |||||
| All-cause deaths, No. | 293 | 163 | 412 | 352 | 321 | 88 | 66 | 129 | 57 | 72 | ||||||||||
| Model 1* | 1.00 | 0.75 | 0.62 to 0.91 | 0.80 | 0.68 to 0.92 | 0.72 | 0.62 to 0.84 | 0.67 | 0.57 to 0.78 | < .001 | 1.00 | 0.80 | 0.58 to 1.10 | 0.65 | 0.50 to 0.85 | 0.48 | 0.34 to 0.67 | 0.49 | 0.36 to 0.67 | < .001 |
| Model 2† | 1.00 | 0.76 | 0.62 to 0.92 | 0.82 | 0.70 to 0.95 | 0.76 | 0.64 to 0.89 | 0.70 | 0.60 to 0.83 | < .001 | 1.00 | 0.86 | 0.63 to 1.20 | 0.72 | 0.55 to 0.94 | 0.54 | 0.38 to 0.75 | 0.55 | 0.40 to 0.75 | < .001 |
| Model 3‡ | 1.00 | 0.80 | 0.66 to 0.98 | 0.90 | 0.77 to 1.05 | 0.84 | 0.71 to 0.98 | 0.80 | 0.68 to 0.95 | .021 | 1.00 | 0.99 | 0.71 to 1.38 | 0.92 | 0.71 to 1.19 | 0.70 | 0.50 to 1.00 | 0.75 | 0.53 to 1.05 | .022 |
| Model 4§ | 1.00 | 1.00 | 0.72 to 1.39 | 0.88 | 0.65 to 1.19 | 0.66 | 0.46 to 0.94 | 0.69 | 0.49 to 0.98 | .006 | ||||||||||
| CRC deaths, No. | 126 | 75 | 199 | 183 | 162 | 26 | 19 | 45 | 19 | 19 | ||||||||||
| Model 1* | 1.00 | 0.90 | 0.67 to 1.19 | 0.90 | 0.72 to 1.12 | 0.89 | 0.71 to 1.12 | 0.81 | 0.64 to 1.02 | .159 | 1.00 | 0.80 | 0.44 to 1.44 | 0.78 | 0.48 to 1.26 | 0.56 | 0.31 to 1.02 | 0.45 | 0.25 to 0.81 | .004 |
| Model 2† | 1.00 | 0.82 | 0.61 to 1.11 | 0.89 | 0.71 to 1.13 | 0.89 | 0.71 to 1.13 | 0.81 | 0.64 to 1.03 | .178 | 1.00 | 0.85 | 0.47 to 1.54 | 0.86 | 0.53 to 1.40 | 0.62 | 0.34 to 1.14 | 0.50 | 0.28 to 0.92 | .014 |
| Model 3‡ | 1.00 | 0.83 | 0.62 to 1.11 | 0.93 | 0.74 to 1.17 | 0.91 | 0.72 to 1.16 | 0.84 | 0.66 to 1.07 | .281 | 1.00 | 0.97 | 0.53 to 1.78 | 1.07 | 0.64 to 1.78 | 0.80 | 0.43 to 1.48 | 0.66 | 0.35 to 1.24 | .155 |
| Model 4§ | 1.00 | 0.98 | 0.53 to 1.81 | 0.96 | 0.57 to 1.62 | 0.69 | 0.36 to 1.29 | 0.53 | 0.27 to 1.03 | .041 | ||||||||||
| CVD deaths, No. | 60 | 23 | 65 | 46 | 50 | 17 | 12 | 30 | 6 | 17 | ||||||||||
| Model 1* | 1.00 | 0.51 | 0.31 to 0.82 | 0.61 | 0.43 to 0.86 | 0.44 | 0.30 to 0.65 | 0.49 | 0.34 to 0.71 | < .001 | 1.00 | 0.73 | 0.35 to 1.53 | 0.77 | 0.43 to 1.40 | 0.26 | 0.10 to 0.66 | 0.58 | 0.29 to 1.13 | .026 |
| Model 2† | 1.00 | 0.51 | 0.32 to 0.83 | 0.67 | 0.47 to 0.95 | 0.50 | 0.34 to 0.74 | 0.55 | 0.38 to 0.81 | .002 | 1.00 | 0.80 | 0.38 to 1.69 | 0.86 | 0.47 to 1.58 | 0.28 | 0.11 to 0.73 | 0.66 | 0.33 to 1.31 | .065 |
| Model 3‡ | 1.00 | 0.58 | 0.35 to 0.94 | 0.82 | 0.57 to 1.18 | 0.66 | 0.44 to 0.98 | 0.78 | 0.52 to 1.15 | .239 | 1.00 | 0.88 | 0.42 to 1.87 | 1.11 | 0.59 to 2.06 | 0.39 | 0.15 to 1.02 | 0.87 | 0.43 to 1.77 | .361 |
| Model 4§ | 1.00 | 0.90 | 0.42 to 1.92 | 1.11 | 0.59 to 2.12 | 0.40 | 0.15 to 1.05 | 0.89 | 0.42 to 1.86 | .382 | ||||||||||
Abbreviations: CRC, colorectal cancer; CVD, cardiovascular disease; HR, hazard ratio; LTPA, leisure time physical activity; NIH, National Institutes of Health.
Model 1 used age as the underlying time metric and was adjusted for sex (male, female).
Model 2 was additionally adjusted for tumor site (colon, rectum), tumor grade, tumor stage (local, regional, unknown), surgery (yes, no), radiation (yes, no), chemotherapy (yes, no), time reported watching television (0 to 2, 3, ≥ 4 h/wk), and smoking status (never, former, current).
Model 3 was adjusted for all covariates in model 2 and also for body mass index (continuous kg/m2) and self-reported health (excellent/very good, good, fair, poor).
Model 4 used the same adjusting variables as model 3, but was mutually adjusted for pre- and postdiagnosis LTPA.