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. 2014 Sep 25;5(21):10293–10306. doi: 10.18632/oncotarget.2511

Figure 2. CAMK2N1 expression was down-regulated by androgen/AR signaling.

Figure 2

(A-B) LNCaP cells were treated with 1-100 nM R1881 for 6-10 hrs. CAMK2N1 mRNA levels were determined by qRT-PCR. (C-E) CAMK2N1, AR protein and mRNA levels were determined by Western blot and qRT-PCR in LNCaP cells with stably knockdown of AR. LNCaP cells were treated with 10 nM R1881 for 10 hrs. (F-H) CAMK2N1 promoter reporters (−39~−1011, −1112~−2006) were assessed in AR-positive LNCaP cells and AR-negative PC3 cells. R1881 repressed activity of CAMK2N1 gene reporters (−39~−1011) in the presence of AR.