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. 2014 Jul 25;5(21):10460–10472. doi: 10.18632/oncotarget.2260

Figure 4. BEZ235 and BGT226 increase survival and reduce ALL in mice.

Figure 4

NOD/SCID mice engrafted with the indicated human ALL samples were treated as shown when blasts in the peripheral blood reached >1% as indicated by the arrow below the plots. (A) Kaplan-Meier plots of the surviving fraction are shown. (B) The number of ALL cells in the peripheral blood, as determined by weekly bleeds. The start of treatment is indicated by the arrow. (C) The in vitro responses of the xenograft cells to the inhibitors as described in Figure 1C.