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. 2014 Sep 25;5(21):10571–10583. doi: 10.18632/oncotarget.2512

Figure 1. SOX10 is frequently silenced by promoter CpG methylation in multiple carcinomas.

Figure 1

(A) Schematic structure of the SOX10 CpG island. Exon 1,2 (indicated with a black rectangle), CpG sites (short vertical lines). (B) SOX10 is broadly expressed in human normal adult tissues and fetal tissues. (C) SOX10 is frequently silenced and methylated in colorectal, esophageal and gastric carcinoma cell lines. Ca, carcinoma; CRC, colorectal cancer; ESCC, esophageal carcinoma; M, methylated; U, unmethylated. (D) Pharmacologic demethylation with Aza alone or combined with TSA (A+T), or (E) genetic demthylation in DKO cell line restored SOX10 expression in methylated/silenced tumor cell lines.