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. 2014 Sep 25;5(21):10584–10595. doi: 10.18632/oncotarget.2513

Fig.3. AR upregulates MMP9, which depends on the phosphorylation of AKT in vitro.

Fig.3

(a) Up: AR overexpression upregulated MMP9 (Left). Bar charts represented relative expression of different proteins (Right). Low: AR knockdown by siRNA or inhibitor decreased MMP9 expression. (b) Influence of AKT activity inhibition on endogenous expression of AR. The AR protein level was decreased significantly by siRNA or the inhibitor of AKT, which was accompanied by a decrease in MMP9 expression (Left). Bar charts represented relative expression of different proteins (Right). (c) Effect of AKT inhibition on AR protein expression in stably transfected SGC-7901 cells. AR protein expression was significantly downregulated by inhibition of AKT, which was accompanied by a decrease in MMP9 expression. Results are the mean of three independent experiments ± SD (*P<0.05).