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. 2014 Sep 25;5(21):10584–10595. doi: 10.18632/oncotarget.2513

Fig.5. Effect of AR inhibition on the migration, invasion and proliferation of SGC-7901 cells.

Fig.5

(a) Enhanced motility of AR-overexpressing cells in the wound healing assay was reversed by inhibition of AR, AKT or MMP9 (Up). Wound healing curve (Low). (b) CCK8 cell proliferation curve. Enhancement of AR-overexpressing cell proliferation was inhibited by suppression of AR or AKT. (c) Transwell assays. The migration-promoting effect induced by AR upregulation was prevented by downregulation of AR or MMP9 or inhibition of AKT in vitro (Up). Histograms showed the cell numbers per field of migration (Low). (d) Histograms showed the cell numbers per field of invasion (Up). The invasion-promoting effect induced by AR upregulation was prevented by downregulation of AR, MMP9 or inhibition of AKT in vitro (Low). Results are the mean of three independent experiments ± SD (*P<0.05) (original magnification, ×200).