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. 2014 Sep 26;5(21):10678–10691. doi: 10.18632/oncotarget.2528

Fig 4. Effects of caspase inhibition on VMY-induced cell death.

Fig 4

Single and dual inhibition of caspases 8 and 9 was performed. LnCAP cells were pretreated with 20 uM of the caspase 8 inhibitor Z-IETD-FMK (Casp 8 Inhibitor), the caspase 9 inhibitor Z-LEHD-FMK (Casp 9 Inhibitor) or both, followed by treatment with 30 uM VMY for 18 hrs. (A) Cell viability as assessed by trypan blue dye exclusion. (B) The proportion of cells undergoing apoptotic cell death as assessed using annexin V staining and measured by flow cytometry. *, p< 0.05