Figure 5. Tumor growth in CXCL4^47–70- and CXCL4L1^47–70-treated tumor-bearing mice.

Progressive tumor growth was assessed in SCID mice, subcutaneously inoculated with MDA-MB-231 tumor cells on day 0 and subsequently treated intratumorally with vehicle (CO), CXCL4^47–70 or CXCL4L1^47–70 (2.5 μg; 3×/week from day 3 onwards). The tumor volume was measured externally with calipers thrice a week and calculated using the formula (4πab2)/3 in which a and b are the largest and smallest radius, respectively. Growth curves represent increasing mean tumor volumes. n=10/group; **p<0.01 (CXCL4^47–70 versus CO); $p<0.05, $$p<0.01 (CXCL4L1^47–70 versus CO)