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. 2014 Apr 24;5(21):10949–10958. doi: 10.18632/oncotarget.1919

Figure 2. Figure 2: Anti-tumor function of the N1/28z chimera.

Figure 2

(A) Human primary lymphocytes were transduced with a retroviral vector encoding either N1/28z or NGFR (control). Transduced T cells were analyzed for NCR1 or NGFR expression 72 h after transduction by flow cytometry. The results are representative of 8 independent experiments performed with 6 different donors. (B) These cells were co-cultured with different tumor lines or normal PBLs as indicated. IL-2 (upper panel), IFNγ(middle panel) and TNFα (lower panel) secreted in the co-culture supernatant was measured by ELISA. These results are representative of four independent experiments, performed with three different donors and the difference between the N1/28z and NGFR populations was found statistically significant (p<0.05, calculated using a Student's paired t-test).