Figure 1.

Target gene selection and the generation of molecular classifiers. A: Schematic showing the distribution of gene transcripts that were assayed in the initial and final profiling panels. B: Schematic outlining the protocols for the molecular classification of all aggressive B-cell lymphomas and cases with the pathological diagnosis of diffuse large B-cell lymphoma (DLBCL) and B-cell lymphoma unclassifiable (BCL-U). Twenty-one genes were used for the Diagnostic classifier, and 61 genes were used for the MYC activity classifier. In addition, eight genes were common to both classifiers, and there were six housekeeping genes (HK).