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. 2015 Jan;17(1):19–30. doi: 10.1016/j.jmoldx.2014.08.006

Figure 4.

Figure 4

A: Scatterplot shows the mean TCF3 signature (seven genes, x axis) and mean MYC signature (10 genes, y axis) for each tumor from the test cohort. The mean values for each signature are derived from transcript counts from these genes, as originally used in the diagnostic classifier. Colors indicate the pathological/genetic diagnoses [black for Burkitt lymphoma (BL), gray for diffuse large B-cell lymphoma (DLBCL), and yellow for genetic double hit lymphomas (DHLs)]. Shapes indicate the molecular classification assigned by the diagnostic classifier [triangle for molecular (m)BL, circle for molecular DLBCL (mDLBCL), and square for molecularly intermediate]. B: Histomorphological features of lymphomas with a MYC rearrangement and either a BCL2- or BCL6- rearrangement (genetic DHL). H&E-stained sections of DHL classified as mBL and mDLBCL. Unique identifiers and details of relevant translocations are shown. The tumors classified as mDLBCL have insets highlighting nuclear morphological characteristics. Original magnification, ×1000 (main images and insets).