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. 2014 Nov;5(11-12):378–392. doi: 10.18632/genesandcancer.39

Figure 5. Activation of JAK/STAT signaling is accompanied by the down regulation of CD45.

Figure 5

(A) Analysis of STAT3, STAT5, and JAK2 activation by western blotting in DEK/NUP214- and PML/RARα-positive U937 cells. Numbers below represent the fold change of the phosphoprotein intensity normalized to the corresponding total level and compared to the control lane (B) Western blot analysis of STAT5 and JAK2 and their phosphorylated form (Y694 and Y1007/1008, respectively) in DEK/NUP214-positive and PML/RARα-positive leukemic cells (C) Flow cytometric analysis of CD45 for bone marrow cells from PML/RARα, DEK/NUP214 and RUNX1/RUNX1T1 leukemia mice compared to bone marrow from wild-type mice.