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. Author manuscript; available in PMC: 2015 Nov 21.
Published in final edited form as: J Mater Chem B. 2014 Nov 21;2(43):7524–7533. doi: 10.1039/C4TB01046A

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Figure 7

Retention and sustained release of rhBMP-2 from mineralized PSBMA hydrogel. (a) Sequestering efficiency of the rhBMP-2 by PSBMA hydrogels and mineralized PSBMA after 2-h incubation in PBS. 300-ng rhBMP-2 was loaded to each specimen. (b) rhBMP-2 release profiles from PSBMA and mineralized PSBMA hydrogels. (c) SEM images micrographs (surface & cross-section views) of the mineralized PSBMA hydrogel at different magnifications. H = hydrogel, SM = surface mineral domains, and IM = interior mineral domains. (d) Robust osteogenic trans-differentiation of C2C12 cells induced by the rhBMP-2 released from mineralized PSBMA hydrogel from day 7 to day 9 (pre-incubated in PBS for 6 days prior to placement in C2C12 culture). C2C12 culture directly supplemented with 300-ng rhBMP-2 without any hydrogel carrier served as a positive control.