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. 2014 Dec 18;2:169. doi: 10.1186/s40478-014-0169-8

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© Kaiser et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Microglial rarefication and activation in the brain of SHR. Total amounts of Iba1-positive microglia (green) in the total brain and deep cortical region (DCR) did not differ strain-dependently (A). However, distances between adjacent cells were significantly greater in SHR compared to WKY (A). Single cell morphological analysis of microglia within the DCR showed similar dendrite lengths, but increased cell volumes in SHR (B). (C) Mean fluorescence intensities (MFI) of microglial CD11b expression were significantly higher in SHR. The representative histogram illustrates the shift towards increased CD11b expression in SHR. Data are mean ± SD. *p < 0.05, **p < 0.01 by one or two-way ANOVA (A) or t-test (B and C) for n = 4 animals/group, scale bar: 30 μm (A), 8 μm (B).