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. 2014 Dec 18;2:169. doi: 10.1186/s40478-014-0169-8

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© Kaiser et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Brain leukocyte subpopulations differ between SHR and WKY. Brains of SHR and WKY contained comparable numbers of CD45 high leukocytes while the composition of subpopulations was strongly different (A). NK cells constituted the predominant immune cell type in SHR. By contrast, the proportion of T cells and monocytes/macrophages (Mo/Mɸ) was higher in WKY. Absolute counts of Mo/Mɸ were decreased (B) whereas NK cells were significantly increased in brains of SHR (C). Immunofluorescence analysis revealed that CD161 positive NK cells (green) were exclusively located in the brain microvasculature (visualized by solanum tuberosum lectin, STL; red) of SHR. Data are mean ± SD. *p < 0.05 by t-test for n = 3 animals/group, scale bar: 10 μm. PMN, polymorphonuclear granulocytes.