Table 1.

Pooled analysis of studies exploring the role of TLR4 Asp299Gly in CD

Study	Cases (Events/Total)	Controls (Events/Total)	Odds ratio	95% CI	P value
Arnott et al. 2004 [ 31 ]	50/468	33/378	1,25	0,79 to 1,98
Franchimont et al. 2004 [ 32 ] (1)	73/668	14/278	2,31	1,28 to 4,17
Franchimont et al. 2004 [ 32 ] (2)	26/226	14/278	2,45	1,25 to 4,81
Torok et al. 2004 [ 33 ]	14/204	12/290	1,70	0,77 to 3,77
Braat et al. 2005 [ 34 ]	68/822	13/274	1,81	0,98 to 3,33
Brand et al. 2005 [ 22 ]	29/408	15/398	1,95	1,03 to 3,70
Lakatos et al. 2005 [ 35 ]	104/1054	48/400	0,80	0,56 to 1,15
Gazouli et al. 2005 [ 36 ]	19/240	6/200	2,78	1,09 to 7,10
Oostenbrug et al. 2005 [ 37 ]	53/786	27/592	1,51	0,94 to 2,43
Ouburg et al. 2005 [ 38 ]	23/224	18/340	2,04	1,08 to 3,88
Fries et al. 2005 [ 39 ] (1)	2/46	2/118	2,63	0,36 to 19,29
Fries et al. 2005 [ 39 ] (2)	10/120	2/118	5,27	1,13 to 24,60
Zouiten-Mekki et al. 2009 [ 40 ]	12/180	9/160	1,19	0,49 to 2,92
Hong et al. 2007 [ 41 ]	26/364	32/376	0,82	0,48 to 1,42
Baumgart et al. 2007 [ 21 ] (1)	6/288	16/404	0,51	0,20 to 1,33
Baumgart et al. 2007 [ 21 ] (2)	28/482	49/806	0,95	0,59 to 1,54
Browning et al. 2007 [ 42 ]	50/778	44/832	1,23	0,81 to 1,86
De Ridder et al. 2007 [ 23 ] (1)	11/144	20/488	1,93	0,91 to 4,14
De Ridder et al. 2007 [ 23 ] (2)	63/756	20/488	2,12	1,27 to 3,56
Riis et al. 2007 [ 43 ]	32/422	152/1236	0,58	0,39 to 0,87
Hume et al. 2008 [ 44 ]	87/1238	36/720	1,43	0,96 to 2,14
Rigoli et al. 2008 [ 45 ]	10/266	8/206	0,96	0,38 to 2,49
Manolakis et al. 2013 [ 46 ]	20/326	33/548	1,02	0,58 to 1,81
Current study 2014	9/166	10/224	1,22	0,49 to 3,09
Total (fixed effects)	825/10676	633/10152	1,26	1,13 to 1,42	0.0001
Total (random effects)	825/10676	633/10152	1,35	1,12 to 1,64