Table 3.

Pooled analysis of studies exploring the role of TLR4 Thr399Ile in CD

Study	Sample size	Cases (Events/Total)	Controls (Events/Total)	Odds ratio	95% CI	P value
Torok et al. 2004 [ 33 ]	CD: 102	16/204	12/290	1.972	0.91 to 4.26
	HC: 145
Braat et al. 2005 [ 34 ]	CD: 204	30/408	19/398	1.583	0.87 to 2.86
	HC: 199
Gazouli et al. 2005 [ 36 ]	CD: 120	1/240	2/200	0.414	0.037 to 4.60
	HC: 100
Oostenbrug et al. 2005 [ 37 ]	CD: 393	69/1008	29/598	1.442	0.92 to 2.25
	HC: 296
Zouiten-Mekki et al. 2009 [ 40 ]	CD: 90	13/180	8/160	1.479	0.59 to 3.66
	HC: 80
Hong et al. 2007 [ 41 ]	CD: 182	30/364	32/376	0.966	0.57 to 1.62
	HC: 188
Browning et al. 2007 [ 42 ]	CD: 389	47/778	46/832	1.099	0.72 to 1.67
	HC: 416
De Ridder et al. 2007 [ 23 ]	CD: 450	72/900	22/488	1.842	1.12 to 3.00
	HC: 244
Rigoli et al. 2008 [ 45 ]	CD: 133	8/266	6/206	1.034	0.35 to 3.02
	HC:103
Azzam et al. 2012 [ 47 ]	CD: 46	26/92	22/100	1.397	0.72 to 2.69
	HC: 50
Manolakis et al. 2013 [ 46 ]	CD: 163	20/326	33/548	1.020	0.57 to 1.80
	HC: 274
Our study 2014	CD: 83	7/166	3/224	3.243	0.82 to 12.73
	HC: 112
Total (fixed effects)		339/4932	234/4420	1.345	1.12 to 1.60	0.002
Total (random effects)		339/4932	234/4420	1.336	1.11 to 1.59