Table 4.
Pooled analysis of studies exploring the role of TLR4 Thr399Ile in UC
| Study | Sample size | Cases (Events/Total) | Controls (Events/Total) | Odds | 95% CI | P value |
|---|---|---|---|---|---|---|
| Torok et al. 2004 [ 33 ] | UC: 98 | 22/196 | 12/290 | 2.929 | 1.41 to 6.06 | |
| HC: 145 | ||||||
| Gazouli et al. 2005 [ 36 ] | UC: 85 | 3/170 | 2/200 | 1.778 | 0.29 to 10.77 | |
| HC: 100 | ||||||
| Oostenbrug et al. 2005 [ 37 ] | UC: 179 | 24/434 | 19/598 | 1.784 | 0.96 to 3.30 | |
| HC: 296 | ||||||
| Zouiten-Mekki et al. 2009 [ 40 ] | UC: 30 | 2/60 | 2/160 | 2.724 | 0.37 to 19.78 | |
| HC: 80 | ||||||
| Browning et al. 2007 [ 42 ] | UC: 405 | 59/810 | 46/832 | 1.342 | 0.90 to 1.99 | |
| HC: 416 | ||||||
| De Ridder et al. 2007 [ 23 ] | UC: 257 | 34/514 | 22/488 | 1.500 | 0.86 to 2.60 | |
| HC: 244 | ||||||
| Rigoli et al. 2008 [ 45 ] | UC: 45 | 3/90 | 6/206 | 1.149 | 0.28 to 4.70 | |
| HC:103 | ||||||
| Manolakis et al. 2013 [ 46 ] | UC: 187 | 41/374 | 33/548 | 1.921 | 1.19 to 3.10 | |
| HC: 274 | ||||||
| Our study 2014 | UC: 34 | 3/68 | 3/224 | 3.400 | 0.67 to 17.25 | |
| HC: 112 | ||||||
| Total (fixed effects) | 191/2716 | 145/3546 | 1.695 | 1.35 to 2.11 | 0.0001 | |
| Total (random effects) | 191/2716 | 145/3546 | 1.699 | 1.35 to 2.12 |