Table 5.

Pooled analysis of studies exploring the role of TLR4 Asp299Gly in IBD

Study	Sample size	Cases (Events/Total)	Controls (Events/Total)	Odds ratio	95% CI	P value
Arnott et al. 2004 [ 31 ]	IBD: 480	85/960	33/378	1,016	0,667 to 1,54
	HC: 189
Franchimont et al. 2004 [ 32 ]	IBD: 610	131/1220	14/278	2,268	1,286 to 4,00
	HC: 139
Torok et al. 2004 [ 33 ]	IBD: 200	32/400	12/290	2,014	1,019 to 3,98
	HC: 145
Braat et al. 2005 [ 34 ]	IBD: 637	92/1274	13/274	1,563	0,861 to 2,83
	HC: 137
Gazouli et al. 2005 [ 36 ]	IBD: 205	25/410	6/200	2,100	0,847 to 5,20
	HC: 100
Oostenbrug et al. 2005 [ 37 ]	IBD: 572	74/1144	27/592	1,447	0,921 to 2,27
	HC: 296
Baumgart et al. 2007 [ 21 ] (1)	IBD: 262	14/524	16/404	0,666	0,321 to 1,38
	HC: 202
Baumgart et al. 2007 [ 21 ] (2)	IBD: 386	52/772	49/806	1,116	0,745 to 1,67
	HC: 403
Browning et al. 2007 [ 42 ]	IBD: 796	101/1592	44/832	1,213	0,843 to 1,74
	HC: 416
Riis et al. 2007 [ 43 ]	IBD: 615	85/1230	152/1236	0,529	0,401 to 0,69
	HC: 618
De Ridder et al. 2007 [ 23 ]	IBD: 103	15/206	20/488	1,838	0,921 to 3,66
De Ridder et al. 2007 [ 23 ]	IBD: 604	96/1208	20/488	2,020	1,233 to 3,31
	HC: 244
Rigoli et al. 2008 [ 45 ]	IBD: 178	13/356	8/206	0,938	0,382 to 2,30
	HC: 103
Manolakis et al. 2013 [ 46 ]	IBD: 350	61/700	33/548	1,490	0,960 to 2,31
	HC: 274
Our study 2014	IBD:117	15/234	10/224	1,466	0,644 to 3,33
	HC:112
Total (fixed effects)		891/12230	457/7244	1,154	1,021 to 1,30	0.015
Total (random effects)		891/12230	457/7244	1,306	1,006 to 1,69