Table 6.
Pooled analysis of studies exploring the role of TLR4 Thr399Ile in IBD
| Study | Sample size | Cases (Events/Total) | Controls (Events/Total) | Odds | 95% CI | P value |
|---|---|---|---|---|---|---|
| Torok et al. 2004 [ 33 ] | IBD: 200 | 38/400 | 12/290 | 2.432 | 1.24 to 4.74 | |
| HC: 145 | ||||||
| Gazouli et al. 2005 [ 36 ] | IBD: 205 | 4/410 | 2/200 | 0.975 | 0.17 to 5.37 | |
| HC: 100 | ||||||
| Oostenbrug et al. 2005 [ 37 ] | IBD: 721 | 93/1442 | 29/598 | 1.353 | 0.88 to 2.07 | |
| HC: 299 | ||||||
| Zouiten-Mekki et al. 2009 [ 40 ] | IBD: 120 | 15/240 | 8/160 | 1.267 | 0.52 to 3.06 | |
| HC: 80 | ||||||
| Browning et al. 2007 [ 42 ] | IBD: 794 | 106/1588 | 46/832 | 1.222 | 0.85 to 1.74 | |
| HC: 416 | ||||||
| De Ridder et al. 2007 [ 23 ] | IBD: 707 | 106/1414 | 22/488 | 1.717 | 1.07 to 2.75 | |
| HC: 244 | ||||||
| Rigoli et al. 2008 [ 45 ] | IBD: 178 | 12/356 | 6/206 | 1.163 | 0.43 to 3.14 | |
| HC: 103 | ||||||
| Manolakis et al. 2013 [ 46 ] | IBD: 350 | 61/700 | 33/548 | 1.490 | 0.96 to 2.31 | |
| HC: 274 | ||||||
| Our study 2014 | IBD: 117 | 10/234 | 3/224 | 3.289 | 0.89 to 12.11 | |
| HC: 112 | ||||||
| Total (fixed effects) | 445/6784 | 161/3546 | 1.479 | 1.22 to 1.82 | 0.0001 | |
| Total (random effects) | 445/6784 | 161/3546 | 1.465 | 1.21 to 1.80 |