Table 9.
Genotype-phenotype correlations in patients with Crohn’s disease
| Parameter | N | Asp299gly (%) | P value | Chi-square test | Thr399Ile (%) | P value | Chi-square test | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | CC | CT | TT | ||||||
| Age of onset | 83 | 0.48 | 1.45 | 0.59 | 1.05 | ||||||
| <17 years | 10 | 10 (100.0) | - | 10 (100.0) | - | ||||||
| 17-40 | 63 | 55 (87.3.) | 8 (12.7) | 57 (90.5) | 6 (9.5) | ||||||
| >40 years | 10 | 9 (90.0) | 1 (10.0) | 9 (90.0) | 1 (10.0) | ||||||
| Sex | 83 | 0.35 | 0.87 | 0.17 | 1.92 | ||||||
| Woman | 25 | 24 (96.0) | 1 (4.0) | 25 (100.0) | - | ||||||
| Man | 58 | 50 (86.2) | 8 (13.8) | 51 (87.9) | 7 (12.1) | ||||||
| Type | 83 | 0.54 | 2.14 | 0.36 | 3.23 | ||||||
| Fistulizing | 35 | 31 (88.6) | 4 (11.4) | 33 (94.3) | 2 (5.7) | ||||||
| Non fistulizing non stenosing | 24 | 20 (83.3) | 4 (16.7) | 20 (83.3) | (16.7) | ||||||
| Stenosing | 17 | 16 (94.1) | 1 (5.9) | 16 (94.1) | 1 (5.9) | ||||||
| Fistulizing stenosing | 7 | 7 (100.0) | - | 7 (100.0) | - | ||||||
| Localization | 83 | 0.80 | 1.67 | 0.94 | 0.82 | ||||||
| L1 | 30 | 26 (86.7) | 4 (13.3) | 27 (90.0) | 3 (10.0) | ||||||
| L2 | 20 | 17 (85.0) | 3 (5.0) | 18 (90.0) | 2 (10.0) | ||||||
| L3 | 26 | 24 (92.3) | 2 () | 24 (92.3) | 2 (7.7) | ||||||
| L4 | 3 | 3 (100.0) | - | 3 (100.0) | - | ||||||
| L4 + L2 | 4 | 4 (100.0) | - | 4 (100.0) | - | ||||||
| Smoking | 83 | 0.04 | 4.44 | 0.17 | 1.92 | ||||||
| Presence | 33 | 26 (78.8) | 7 (21.2) | 28 (84.8) | 5 (15.2) | ||||||
| Absence | 50 | 48 (96.0) | 2 (4.0) | 48 (96) | 2 (4.0) | ||||||
| SFC | 83 | 0.91 | 0.01 | 0.76 | 0.09 | ||||||
| Presence | 4 | 4 (100.0) | - | 4 (100.0) | - | ||||||
| Absence | 79 | 70 (88.6) | 9 (11.4) | 72 (91.1) | 7 (8.9) | ||||||
| Appendectomy | 83 | 0.84 | 0.04 | 0.58 | 0.30 | ||||||
| Presence | 12 | 11 (91.7) | 1 (8.3) | 10 (83.3) | 2 (16.7) | ||||||
| Absence | 71 | 63 (88.7) | 8 (11.3) | 66 (93.0) | 5 (7.0) | ||||||
| EIM | 83 | 0.97 | 0.001 | 0.97 | 0.001 | ||||||
| Presence | 42 | 38 (90.5) | 4 (9.5) | 39 (92.9) | 3 (7.1) | ||||||
| Absence | 41 | 36 (87.8) | 5 (12.2) | 37 (95.1) | 4 (4.9) | ||||||
| Surgery | 83 | 0.50 | 0.45 | 0.45 | 0.57 | ||||||
| Presence | 41 | 38 (92.7) | 3 (7.3) | 39 (95.1) | 2 (4.9) | ||||||
| Absence | 42 | 36 (85.7) | 6 (14.3) | 37 (88.1) | 5 (11.9) | ||||||
SFC: similar familial cases; EIM: extra intestinal manifestations; N: total number; AA: wild type TLR4 Asp299gly, AG: TLR4 Asp299gly heterozygous variant, GG: TLR4 Asp299gly homozygous variant; CC: wild type TLR4 Thr399Ile, CT: TLR4 Thr399Ile heterozygous variant, TT: TLR4 Thr399Ile homozygous variant.