Table S1.
Haplotypes of HIF1A and their association with COPD risk
| Haplotype | Freq | ORa (95% CI) | P-valuea | |
|---|---|---|---|---|
| Block | GGGACCA | 0.6148 | 1.00 | – |
| GGGACCC | 0.1409 | 0.93 (0.55–1.58) | 0.79 | |
| GCATTTC | 0.0994 | 1.09 (0.62–1.93) | 0.76 | |
| CGGACCA | 0.0977 | 0.74 (0.39–1.37) | 0.34 | |
| GCATTCC | 0.0212 | 1.42 (0.46–4.44) | 0.54 | |
| *******b | 0.0259 | 0.74 (0.21–2.68) | 0.65 | |
| Total | GGGACCAAC | 0.6162 | 1.00 | – |
| GGGACCACC | 0.1221 | 1.06 (0.52–2.14) | 0.88 | |
| GCATTTACT | 0.0997 | 1.28 (0.66–2.49) | 0.46 | |
| CGGACCAAC | 0.0977 | 0.80 (0.39–1.63) | 0.54 | |
| GCATTCACC | 0.0212 | 2.12 (0.55–8.19) | 0.28 | |
| GGGACCCCC | 0.0175 | 0.53 (0.08–3.49) | 0.51 | |
| *********b | 0.0256 | 0.92 (0.21–4.15) | 0.92 |
Notes: P-value ≤0.05 indicates statistical significance;
a
adjusted for sex, age, smoking status.
*******b
is on behalf of the other arrangement of these single nucleotide polymorphisms.
Abbreviations: COPD, chronic obstructive pulmonary disease; Freq, frequency; HIF1A, hypoxia-inducible factor 1α; OR, odds ratio; CI, confidence interval.